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| Caption | Generation of the Pnpla3tm1Eek allele. (A) The native (wild-type, WT) Pnpla3 allele and targeting (knockout, KO) construct (not drawn to scale). Bacterial artificial chromosome (BAC) recombineering was used to replace 1939 bp of the native Pnpla3 gene from position -12 to +1927 including the ATG start signal and the entire exon 1 (which contains the GXSXG motif with the putative critical catalytic serine residue of the patatin domain) by a neomycin resistance cassette. Embryonic stem (ES) cell electroporation, selection, and screening were then performed using standard techniques. | ||||
| Copyright | This image is from Basantani MK, J Lipid Res 2011 Feb;52(2):318-29 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:168857 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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