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| Caption | Generation of the Rr7tm1.1Kio and Rr7tm2.1Kio alleles. Targeting strategy to insert the hCD2-LCR in the mCD8 gene complex. Diagram showing the targeting construct, the homology region of the CD8 gene locus, and the targeted allele with neomycin and after deletion of the neomycin resistance gene for CD8/LCR knock-in mice. Restriction enzymes are indicated by vertical bars (B, BamHI; E, EcoRV; H, HpaI; C, Cla I; X, Xba I). (A) CD8/LCR (cII-III) knock-in construct to generate the Rr7tm1.1Kio allele, (B) CD8/LCR (cIII-IV) knock-in construct to generate the Rr7tm2.1Kio allele: the neomycin resistance gene (striped box) was linked to the hCD2-LCR fragment (light gray box) and flanked by 5' and 3' homologous DNA sequences (dark gray boxes). The HSV-TK gene (white box) in the (cII-III) knock-in construct was added for negative selection. | ||||||
| Copyright | This image is from Menzel U, Proc Natl Acad Sci U S A 2010 Sep 28;107(39):16928-33. Copyright 2010 National Academy of Sciences, U.S.A. J:164573 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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