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| Caption | The Kaos mouse line (LrgukKaos) phenotype was caused by a mutation in the Lrguk gene specifically affecting the LRGUK-1 isoform. (A) The Lrguk gene produces three transcripts in mouse. The Kaos mouse line contained a point mutation (C to T substitution, black arrowhead) located in exon 14 of Lrguk transcripts 1 (Lrguk-1). (B) The Kaos mutation resulted in the conversion of arginine 528 to a stop codon (R528*). LRR = leucine-rich region, LRRCT = leucine-rich repeat C-terminal domain, and GK = guanylate kinase-like domains. | ||||
| Copyright | This image is from Liu Y, PLoS Genet 2015 Mar;11(3):e1005090, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:222840 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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