| Image |
|
||||
| Caption | Generation of the Pphln1Gt(A043F08)Wrst allele. Mapping of the gene trap vector integration site in intron 6 of the murine periphilin-1 gene. The gene trap principle is based on the random integration of a reporter/selector cassette into a genome in order to simultaneously select for, mutate, and identify the trapped locus. Gene trap vectors are promoterless, and the presence of splice donor or acceptor elements leads to the generation of a fusion transcript with the endogenous gene after intron integration. For ES cell clone A043F08, the vector integration site could be mapped to intron 6 of the murine periphilin-1 gene in between exons 6 and 7. Because exon 6 is skipped by alternative splicing, the reporter/selector cassette lies directly downstream of exon 5 in the resulting fusion transcript. Exon 1 is not part of the periphilin-1 coding sequence (CDS), because the start codon lies in exon 2. | ||||
| Copyright | This image is from Soehn AS, Genesis 2009 Jul 20;47(10):697-707, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:153558 | ||||
|
Associated Alleles |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||
Analysis Tools