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Caption Generation of the Bloc1s1tm1Wli and Bloc1s1tm1.1Wli alleles. B, schematic diagram of gene targeting vector of mouse Bloc1s1. Note that exon 2 is engineered to be deleted by inserting two flanking loxp sites in intron 1 and intron 2 and a neomycin (neo) cassette. Using this gene-targeting strategy, the obtained heterozygous Bloc1s1 knock-out mice (Bloc1s1tm1.1Wli) were generated by crossing Bloc1s1tm1Wli (Bloc1s1loxp/+) mice with EII-Cre mice. Intercross of heterozygous Bloc1s1tm1.1Wli mice produced null mutant mice with exon 2 deletion.
Copyright This image is from Zhang A, J Biol Chem 2014 Oct 17;289(42):29180-94 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:238911
Associated
Alleles
Symbol Name
Bloc1s1tm1.1Wli biogenesis of lysosomal organelles complex-1, subunit 1; targeted mutation 1.1, Wei Li
Bloc1s1tm1Wli biogenesis of lysosomal organelles complex-1, subunit 1; targeted mutation 1, Wei Li

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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory