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| Caption | Generation of the Srrm4tm1b(EUCOMM)Wtsi allele. (A, top panel) Map of the conditional allele showing the positions of exons, Frt (open triangles) and LoxP (solid triangles) recombination sites, homology arms (dashed boxes), and cutting sites for the AseI restriction enzyme (vertical arrows) and the probe (solid bar) used for Southern blot analysis. (Bottom panel) Map of the knockout allele following crossing of the conditional nSR100lox mouse with a CMV-Cre transgenic line. Cre-LoxP recombination drives the loss of nSR100 exons 7 and 8 and results in a +2 frameshift and the introduction of several premature termination codons downstream from the deletion. The position of primers used for RT-PCR (horizontal arrows) is indicated. Homozygous mutant mice do not display any overt phenotype. | ||||
| Copyright | This image is from Quesnel-Vallieres M, Genes Dev 2015 Apr 1;29(7):746-59, and is displayed with the permission of Cold Spring Harbor Laboratory Press, who owns the Copyright. J:221584 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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