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| Caption | Generation of the Kdm4btm1.1Okad and Kdm4btm1.2Okad alleles. Conditional gene targeting of murine Kdm4b (Jmjd2b) locus. (A) Introduction of loxP sites into Kdm4b. A portion of the murine wild-type Kdm4b locus showing exon 5 (grey rectangle) and an 11.9 kb XbaI fragment are shown at the top. The targeting vector was designed to generate floxed exon 5 (loxP; black triangles), to flank the PGK-neo cassette with frt sequences (grey triangles), and to introduce a new XbaI site (X). The targeted allele contains a diagnostic 7.7 kb XbaI fragment. The neo cassette was removed in vivo by FLPe recombinase, generating the Kdm4btm1.1Okad allele (flox allele). Cre-mediated recombination resulted in the deletion of exon 5, generating the Kdm4btm1.2Okad allele (delta allele). The position of the 5' flanking probe used for genotyping is indicated. | ||||||
| Copyright | This image is from Kawazu M, PLoS One 2011;6(3):e17830, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171678 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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