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| Caption | Generation of the Gpx4tm4Marc allele. A, gene targeting strategy for the site-directed mutation of Sec to Ser in Gpx4. The upper line depicts the wild-type (WT) allele of Gpx4. The lower line shows the targeting vector used to generate a point mutation in the active site of Gpx4, which is encoded by exon 3 (red box) and marked by an asterisk. The neomycin phosphotransferase gene (neo) was used for positive selection of transfected ES cells. The thymidine kinase gene (TK) is located downstream of the 3' arm for homologous recombination that was utilized for negative selection (BS, pBluescript vector backbone). | ||||
| Copyright | This image is from Ingold I, J Biol Chem 2015 Jun 5;290(23):14668-78 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:225651 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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