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| Caption | Generation of the Kmt2atm1Afst allele. Complete recombination by Flpo but not Flpe of a targeted Kmt2a (Mll1) allele. (a) Scheme of the Kmt2a allele before and after Flp recombination. The LacZ cassette flanked by FRT sites is 6.7kb and was inserted in intron 1 of the Kmt2a locus by targeting. The arrows represent the PCR primers used for detecting recombination. Wild type (wt) and targeted (TG) alleles were distinguished using the PCR primers that flank the loxP site in the second intron. The presence of the LacZ cassette was detected using primers pA and the one 3' of the second intron loxP site. Flp recombination (F) was detected using the primer upstream of the 5' FRT site and the one 3' of the second intron loxP site. | ||||
| Copyright | This image is from Kranz A, Genesis 2010 May 4;():, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:160215 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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