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| Caption | Strategy for the generation of the Trim63tm1.1Vlcg allele showing the Ring-finger domain (gray box) spanning the first two exons of Trim63 (MuRF1) (endogenous locus). The targeting cassette was generated by replacing the first two exons (E1 and E2) of Trim63 with a Myc-encoding sequence fused in-frame with the region of Trim63 encoding D2-S110, followed by a short intron sequence, and a selectable marker (NEO, neomycin resistance gene) (targeted locus). Upon homologous recombination, the floxed NEO cassette was removed with a Cre expression vector (recombined locus). | ||||
| Copyright | This image is from Cohen S, J Cell Biol 2009 Jun 15;185(6):1083-95, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:150424 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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