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| Caption | Generation of the Myo5btm1a(KOMP)Wtsi allele. Using homologous recombination, a trapping element was introduced in intron 4-5 of Myo5b, including the mouse En2 splice acceptor and the SV40 polyadenylation sequences, as well as a neomycin resistance cassette under the control of the human Beta-actin promoter, flanked by FRT sites. This allele is predicted to result in a truncated mRNA containing the first 4 exons of Myo5b followed by an IRES sequence. The strategy used has the potential to be converted into a conditional knockout system by crossing these mice with an Flp deleter mouse. Horizontal black arrows in (B) indicate the location of the PCR primers used for genotyping. | ||||||
| Copyright | This image is from Carton-Garcia F, Sci Rep 2015;5():12312, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:229427 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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