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| Caption | Generation of the Hprt1tm1(CAG-Glra3*)Jcme (GlyR HA-alpha3L185L) allele. (A) Homologous recombination of genOway's "Quick Knock-inTM" targeting vector with the CAG promoter (pCAG), a floxed STOP cassette (loxP sites), and the cDNA coding for HA-tagged GlyR 3L185L (B) repairs the Hprt gene locus on the X-chromosome ('Hprt-HR'). HA = hemagglutinin epitope tag, SP = signal peptide, SV40-PA = SV40-derived poly-adenylation signal, TM = transmembrane domain. | ||||
| Copyright | This image is from Winkelmann A, J Clin Invest 2014 Feb 3;124(2):696-711 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:207981 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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