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| Caption | Targeting strategy of the Foxa2tm2.1Heli (Foxa2FVF) allele: The targeting vector was used to fuse the open reading frames of Foxa2 (orange boxes) to the fluorescent protein reporter gene Venus (yellow arrow). Flp recombinase-mediated excision was used to eliminate the PGK driven Neomycin (neo)-resistant cassette flanked by FRT sites and a 5'loxP site. The coding region (orange boxes) and 5' and 3'UTRs (black boxes) as well as the predicted promoter sites (yellow boxes) and transcriptional start region (TSR, red boxes) are indicated. The location of the 3' external probe and appendent restriction sites EcoRV and SpeI are indicated. Homology regions to generate the targeting construct are indicated as 5' and 3' retrieval. | ||||
| Copyright | This image is from Burtscher I, Genesis 2013 Aug;51(8):596-604, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:204475 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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