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| Caption | Generation of loxP-flanked allele of Lyn. (A) Schematic representation of the gene-targeting construct and screening strategy for obtaining the Lyntm1.1Calo allele. Part of the Lyn genomic locus, the Lyn targeting vector and the targeted Lyn locus before and after Cre-mediated recombination are shown. Exons 2, 3, and 4 are indicated by white boxes. LoxP sites are represented by black triangles, frt sites are open triangles, and the neomycin resistance gene (neor) and herpes simplex virus thymidine kinase gene (tk) are shown as white and gray boxes, respectively. DNA fragments used for Southern-blot analysis are represented as thin lines extending between two restriction sites. Probes 5 and 9 used for Southern-blot analysis are shown as thick lines. LAH, Long Arm of Homology; SAH, Short Arm of Homology. | ||||
| Copyright | This image is from Lamagna C, Proc Natl Acad Sci U S A 2013 Aug 27;110(35):E3311-20. Copyright 2013 National Academy of Sciences, U.S.A. J:200745 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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