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| Caption | (A) Modification of the endogenous Olfr17 (P2) locus by homologous recombination to generate the Or10a4tm3.1Besk (tet-P2Z) allele. (I) The tet-P2Z targeting construct allows bicistronic expression of the P2 odorant receptor protein and the marker protein tau-lacZ,both driven by the tet operator inserted at the start site of transcription of the P2 locus. Flanking P2 promoter regions are preserved in the construct, shifted 5' of the tet operator. (II) The unmodified genomic P2 locus. (III) Homologous recombinationin mouse ES cells followed by self-excision of the angiotensin-converting-enzyme-Cre-LoxP-NeoR-LoxP (ACN) selection cassette yields the tet-P2Z allele. | ||||
| Copyright | This image is from Fleischmann A, PLoS Biol 2013 May;11(5):e1001568, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:201434 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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