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| Caption | (B) Modification of the endogenous P2 locus by homologous recombination to generate the Or10a4tm2.1Besk (tet-P2delta) allele. (I) The tet-P2delta-targeting construct allows expression of the marker protein GFP driven by the tet operator, inserted at the start site of transcription of the Olfr17 (P2) locus, in the absence of the P2 coding region. Flanking P2 promoter regions are preserved in the construct, shifted 5' of the tet operator. (II) The unmodified genomic P2 locus. (III) Homologous recombination in mouse ES cells followed by self-excision of the angiotensin-converting-enzyme-Cre-LoxP-NeoR-LoxP (ACN) selection cassette yields the tet-P2delta allele. | ||||
| Copyright | This image is from Fleischmann A, PLoS Biol 2013 May;11(5):e1001568, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:201434 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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