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| Caption | Generation of the Rhoftm1.2Tac allele employed a targeting strategy which permitted generation of conditional or constitutive knockout (KO) mice. Exons 3 and 4 of the RhoF gene were flanked by LoxP sites and a Neo selection marker was inserted flanked by Frt sites such that deletion of exons 3 and 4 caused a frameshift mutation resulting in loss of function. Initially a conditional ready KO was generated after in vivo Flp-mediated removal of the selection marker. A constitutive KO was then generated after Cre-mediated deletion of exons 3 and 4. Red triangles represent LoxP sites, yellow triangles represent Frt sites. Abbreviations: untranslated region (UTR), frameshift (F-S). | ||||
| Copyright | This image is from Goggs R, PLoS One 2013;8(1):e54663, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195926 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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