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| Caption | Generation of the Pkd1tm1.1Pcha (Pkd1 p.R3277C) allele. (A) Diagram of the targeting construct used for injection into ESCs. Restriction sites flanking the construct are in green (Sb, Sbfl; Mo, MboI). The Pkd1 p.R3277C mutation was introduced using the exact codon found in Autosomal Dominant Polycystic Kidney Disease (ADPKD) probands (red). Restrictions sites used for introducing the mutation and the loxP-flanked (red triangles) selection cassette (yellow box) are in orange (A, AdhI; X, XhoI; S, SalI). The restriction site used to linearize the targeting construct is shown in purple (P, PacI). Restriction sites and probes used for Southern blotting are in blue (Bs, BspHI; M, MfeI). | ||||
| Copyright | This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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