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| Caption | Generation of non-polyalanine repeat expansion mutations (NPARM) Phox2btm1.1Heno and Phox2btm2.1Heno knock-in alleles. (B) Schematics showing the gene-targeting strategy. Gray boxes indicate exons of the Phox2b gene. Red boxes show human genomic fragments spanning from the deletion mutations to the aberrant stop codon due to the shift in the open reading frame (ORF). A floxed (white triangles) Tn5-neo cassette was removed in vivo by Cre recombination. Bars depict the location of the probe for Southern blot analysis and PCR primers for screening the recombined ES clones. | ||||||
| Copyright | This image is from Nagashimada M, J Clin Invest 2012 Sep 4;122(9):3145-58 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190742 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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