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| Caption | Targeted disruption of the murine Ceacam16 gene. A, shown is targeting strategy. Structure of the wild-type allele (top), targeting construct (middle), and recombinant allele (bottom), Ceacam16tm1Wzm, is shown. The 6 exons of Ceacam16 are shown as boxes with the encoded domains indicated above (exons encoding IgV-like domains are red; IgC-like domains are blue). Except for BamHI, only restriction endonuclease sites relevant for cloning or probe generation are shown. Neo and tk expression cassettes, which can be used for the selection of homologous recombinants (G418-and ganciclovir-resistant) are shown as open boxes. Black arrows indicate the transcriptional direction. The vector sequence within the targeting plasmid is shown as a thin line. The positions and predicted sizes of the DNA fragments obtained after digestion with BamHI and hybridization with the 5' - (blue) and 3' - probes (red), respectively, are indicated. Positions of primers used for identification of ES cell clones with homologous recombination, genotyping, and detection of Ceacam16 transcripts are shown by half arrows. | ||||
| Copyright | This image is from Kammerer R, J Biol Chem 2012 Jun 22;287(26):21584-98 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:187537 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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