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| Caption | Creation of the Pank2tm1.1Suja allele. A selection cassette containing cDNA encoding thymidine kinase (TK) and neomycin resistance (NEO) was inserted into the intron between exons 2 (Ex2) and 3 (Ex3) of the Pank2 gene. The cassette was flanked by loxP (c) sites. A third loxP site was inserted between exons 3 (Ex3) and 4 (Ex4). Cre-recombinase-mediated deletion of the DNA between the outermost loxP sites resulted in a knockout (KO) allele which lacked Ex3 and lacked the selection cassette. Locations of the primers (arrows) for PCR genotyping are shown. PCR products and sizes are indicated (bars), and B indicates the presence of a BamHI site. | ||||
| Copyright | This image is from Garcia M, PLoS One 2012;7(7):e40871, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:189609 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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