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| Caption | Targeting strategy for the conditional deletion of exon 2 and 3 of the murine Cldn10 gene. A FRT/loxP site-flanked neomycin cassette was inserted upstream of exon 2, and a loxP site was inserted downstream of exon 3. The neomycin cassette was removed via FLP-mediated recombinase and generated the Cldn10tm1.1Dmu (floxed) allele. Cre-mediated recombinase can be used to conditionally remove exon 2 and 3 (deleted). dta, dta-cassette containing dta under control of the murine pGK promotor; neo, neo cassette containing neomycin resistance under control of the murine pGK promotor. Filled triangles indicate a loxP site; open triangles, FRT sites. | ||||
| Copyright | This image is from Breiderhoff T, Proc Natl Acad Sci U S A 2012 Aug 28;109(35):14241-6. Copyright 2012 National Academy of Sciences, U.S.A. J:188580 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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