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| Caption | (A) Schematic representations of (i) a portion of the mouse NuMA gene including exons 16-25 and EcoRI restriction sites, (ii) the exon 22 targeting vector showing the neomycin resistance (Neo) and diphtheria toxin (DT) cassettes and placement of loxP and FRT sites, (iii) the structure of the correctly targeted allele with the introduced SacII restriction site and locations of genotyping primers (Numa1tm1Dwc), (iv) the conditional allele (flox) produced by Flp-enhanced recombinase-mediated recombination of FRT sites flanking Neo (Numa1tm1.1Dwc), and (v) the deletion allele (delta22) produced by Cre recombination of loxP sites surrounding exon 22 (Numa1tm1.2Dwc). Red bars indicated exon 22. | ||||||||
| Copyright | This image is from Silk AD, J Cell Biol 2009 Mar 9;184(5):677-90, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:146214 | ||||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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