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| Caption | Generation of the Sirt6tm2.1Cxd and Sirt6tm2.2Cxd alleles. A-C, targeted disruption of Sirt6 in mice. The Sirt6 targeting construct contains three loxP sites, one in intron 1 (LoxP3) and two flanked a neo gene (LoxP1 and P2) (A). Homologous recombination in embryonic stem (ES) cells can generate two types of mutant ES cells, i.e. mutant-1 that loses the third loxP site (B) and mutant-2 that maintains the third loxP site (C). Mutant-1 results in the Sirt6tm2.1Cxd allele. Exons 2 and 3 are deleted by crossing with a Tg(EIIa-cre)C5379Lmgd (EIIa-Cre) mouse and this generates the Sirt6tm2.2Cxd allele. | ||||||
| Copyright | This image is from Xiao C, J Biol Chem 2010 Nov 19;285(47):36776-84 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167023 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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