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| Caption | Targeting of murine L3mbtl1. Detailed diagram of the murine L3mbtl1 genomic locus and targeting strategy. Shown are the wild-type allele (top), the targeting vector (second), the targeted allele (third), and the knockout allele, L3mbtl1tm1.1Haho, generated by transient expression of Cre in targeted ES-cells in vitro (bottom). Note that Cre-mediated excision deletes exon 13-20 and generates a frame shift between exon 12 and 21. Thus, the two C-terminal MBTdomains, zinc-finger and SAM-domain are disrupted in the knockout allele. | ||||
| Copyright | This image is from Qin J, J Biol Chem 2010 Sep 3;285(36):27767-75 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166180 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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