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| Caption | A, gene-targeting strategy to create a mutant Lmna allele, Lmnatm7Lgf (LmnaLAO), that yields exclusively mature lamin A. After recombination, introns 10 and 11 are deleted, thereby abolishing the synthesis of lamin C. Also, the last 30 bp of exon 11 and the first 24 bp of exon 12 are removed, placing the last codon within mature lamin A adjacent to the prelamin A stop codon (asterisk). Exon 12 sequences are indicated in gray. Exons are depicted as boxes; the position of the 5'-flanking probe and relevant restriction sites are also included. | ||||
| Copyright | This image is from Coffinier C, J Biol Chem 2010 Jul 2;285(27):20818-26 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165928 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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