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| Caption | Targeting of Fcgr2b to generate the Fcgr2btm1.1Rav allele. (A) To generate a loxPneo allele for Fcgr2b using standard gene targeting techniques in ES cells, the loxP neo cassette was inserted between the transmembrane domain (TM) and the first intracellular domain. A third loxP site was inserted 5' to the first extracellular domain to complete the conditional targeting construct. Black boxes represent the coding regions of the Fcgr2b gene, and gray triangles represent the loxP sites. RI, EcoRI; RV, EcoRV. Expected sizes of EcoRV-digested genomic DNA for the wild-type and targeted alleles are shown. The neo cassette was removed via cre-mediated recombination. | ||||
| Copyright | This image is from Smith P, Proc Natl Acad Sci U S A 2012 Apr 17;109(16):6181-6. Copyright 2012 National Academy of Sciences, U.S.A. J:183615 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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