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| Caption | (A) Top: The structure of targeting vector containing a loxP-flanked (bgeo/stop) cassette with CT-GFP pA target gene. A pROSA26-1 plasmid contains ROSA26 genomic sequences and a diphtheria toxin gene (PGK-DTA) to increase rate of homologous recombination and negative selection in ES cells, respectively. Middle: the genomic organization of endogenous ROSA26 locus. The structure of the targeted Gt(ROSA)26Sortm1Uga allele (R26CT) which expresses beta-galactosidase and a neomycin resistance cassette fusion gene mRNA. Bottom: Cre-mediated excision of targeted mutant allele to transcribe CT-GFP mRNA. loxP, solid arrow head; bgeo, a fusion gene of beta-galactosidase and neomycin (Neo) resistant gene; pA, polyA signal; STOP, a transcription stop sequence. | ||||
| Copyright | This image is from Ha S, BMC Neurosci 2011;12():97, an open-access article, licensee BioMed Central Ltd. J:179833 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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