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| Caption | Generation of Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+ mice. (A and B) Targeting strategy. Insertion of the targeting vector ROSA26-STOP-Kir6.2V59M (B) into the ROSA26 locus (A) by homologous recombination in mouse ES cells. (C) Targeted ROSA locus. (D) After Cre-mediated deletion of the STOP cassette, Kir6.2-V59M is expressed under the control of the endogenous ROSA26 promoter. 1-3, ROSA26 exons 1-3; SA, splice acceptor signal; PGK-Neo, neomycin resistance gene; STOP, transcriptional STOP signal; DT-A, diphtheria toxin A; pA, polyadenylation signal; E, EcoRI restriction site; P, PacI restriction site; FRT, flippase recombinase target site. | ||||
| Copyright | This image is from Girard CA, J Clin Invest 2009 Jan;119(1):80-90 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:144715 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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