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| Caption | Emu deletion and VH gene insertion in an Igha locus to generate the Ightm1Leck allele. (A) Targeting strategy. WTb, WT Ighb locus. Thick vertical bars show exons for DQ52, JH1-4, and the first two exons of Cmu. Smu, mu switch region; shaded oval, Emu; B, BamHI; H, HindIII; WTa, unmodified Igha locus. Shaded boxes (5'H and 3'H) show regions of homology with targeting vector. Targeting vector: LoxPNeoR, loxP-flanked neomycin resistance gene (white arrowheads indicate loxP sites), B1-8VH promoter region (shaded), and coding sequences (thick vertical lines). neoRVHdeltaa:Igha allele after homologous recombination. Ightm1Leck (VHdealtaa), modified Igha allele after neoR gene deletion. | ||||
| Copyright | This image is from Li F, J Exp Med 2009 Jan 16;206(1):153-67, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:144033 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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