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| Caption | Generation of the Runx1tm2.1(cre/Esr1*)Ims allele. An Engrailed-2 splice acceptor (En2SA) signal, tamoxifen-dependent cre recombinase sequence (cre/Esr1*; MerCreMer), STOP signal and floxed neo selection marker were inserted into the Runx1 gene. Arrowheads indicate relative positions and orientations of PCR primers used for genotyping. Sizes and locations of genomic BamHI restriction fragments hybridizing with external and internal probes are shown. Open boxes or vertical bars represent exons, red indicates coding sequence, yellow rectangle shows exogenous En2 splice acceptor site, black rectangle represents transcription stop cassette and black ovals indicate Runx1 promoters. | ||||
| Copyright | This image is from Tanaka Y, Proc Natl Acad Sci U S A 2012 Mar 20;109(12):4515-20. Copyright 2012 National Academy of Sciences, U.S.A. J:182232 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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