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| Caption | Disruption of the Nfkbib gene. (A) Schematic structure of wild-type Nfkbib locus (IkappaBbeta wt locus). Ankyrin repeats of Nfkbib encoded by exons 2-5 are indicated. Furthermore, the targeting vector, the targeted Nfkbib locus, the floxed Nfkbib locus, and the Nfkbibtm1.2Rsch knock-out locus, generated by Cre recombination-mediated deletion of exons 4 and 5 are shown. Solid boxes represent exons, and lines represent introns. Neo, loxP-flanked PGK-neomycin cassette; HSV-tk, HSV-thymidine kinase gene; B, BamHI site. The length of BamHI-generated restriction fragments detected by Southern blotting with a 5N flanking probe is indicated. Location of the 5N flanking probe in exon 2 is shown. | ||||
| Copyright | This image is from Scheibel M, J Exp Med 2010 Nov 22;207(12):2621-30, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:176877 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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