Gene Expression Image Detail

Reference

Figure

ID

J:110617 Stottmann RW, et al., Dev Biol. 2006 Jul 15;295(2):647-63

2

MGI:7367137

Image

Caption

(A-D) Whole mount in situ hybridization in control (A and B) and Nog-/- (C and D) embryos at E9. (A) Wild-type embryo, lateral view. (B) Wild-type embryo, dorsal view. (C) Nog-/- embryo, lateral view, with exencephaly from caudal forebrain to caudal hindbrain (region between the arrows). (D) Nog-/- embryo, broad distance between the dorsal neural folds (doubleheaded arrow) should be closed as in the control embryo. (I-K) Frontal sections of E10 littermates from Nog+/- intercross stained for NoglacZ activity. (K) A more rostral section of mutant showing convex curvature of each side of the neural plate due to failure to bend medially at sites where dorsolateral hinge point should form (arrows).

Copyright

Reprinted with permission from Elsevier from 10.1016/j.ydbio.2006.03.051 Dev Biol 295: 647-63, Stottmann RW; Berrong M; Matta K; Choi M; Klingensmith J, The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. Copyright 2006.

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
A	MGI:7367138 (Msx1)
B	MGI:7367138 (Msx1)
C	MGI:7367138 (Msx1)
D	MGI:7367138 (Msx1)
I	MGI:7367141 (Nog)
J	MGI:7367141 (Nog)
K	MGI:7367141 (Nog)