Phenotype Image Detail

Image

Caption

A leucine-to-proline substitution in the FGF domain of FGF10 leads to absence of limbs and lungs. Wild-type (WT) E10.5 embryo (A) and Fgf10^ptls/Fgf10^ptls (Fgf10^L91P) embryo (B) displaying lack of limb buds at E10.5. In (A), yellow and orange arrows indicate location of fore and hind limbs (FL, HL), respectively, and similar arrows indicate in (B) the areas where they would have been expected to appear. (C,D) Comparison by bone staining of WT (C) and mutant (D) E15.5 embryos. In the mutant, clavicle (Clav), parts of the scapulae (Sc) and rudimentary iliac bones (il) are present, but fore- and hind limb bones are absent (D). (E,F) Histological sections of E11.5 WT (E) and mutant (F) embryos at a thoracic level. Lu in (F) indicates the lungs.

Copyright

This image is from Wansleeben C, PLoS One 2011;6(4):e19357, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:173681

Associated Alleles

Symbol	Name
Fgf10^ptls	fibroblast growth factor 10; pootloos

Associated Genotypes

Allelic Composition	Genetic Background
Fgf10^ptls/Fgf10^ptls	involves: C57BL/6 * FVB/N