Phenotype Image Detail

Image

Caption

KATNAL2 regulates the manchette, and thus spermatid head shaping. (a) Electron microscopy showing nuclear morphology of elongating spermatids in wild-type (Katnal2^WT/WT) and Katnal2^m1Anu/Katnal2^m1Anu (Katnal2^Y86C/Y86C) mice. Excessive constriction of the perinuclear ring (arrowheads) was observed in the mutant but not wild-type (WT) mice. Scale bars in a = 2 um. (b) Alpha-tubulin immunolabelling as a marker for spermatid manchettes in WT and mutant testis sections. Scale bars in b = 10 um.

Copyright

This image is from Dunleavy JEM, PLoS Genet 2017 Nov;13(11):e1007078, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:250115

Associated Alleles

Symbol	Name
Katnal2^m1Anu	katanin p60 subunit A-like 2; mutation 1, Australian National University

Associated Genotypes

Allelic Composition	Genetic Background
Katnal2^m1Anu/Katnal2^m1Anu	C57BL/6J-Katnal2^m1Anu