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Phenotype Image Detail
Image
Caption Il21rtm1Wjl/Il21r+ X/Yaa (Il21r+/-) but not Il21rtm1Wjl/Il21rtm1Wjl X/Yaa (Il21r-/-) spleens lack an obvious marginal zone (MZ) and show expansion in red pulp with monocytosis and accumulations of plasma cells resulting in compression of the white pulp. Central arteriole (CA), follicle (F) of H&E-stained sections.
Copyright This image is from Bubier JA, Proc Natl Acad Sci U S A 2009 Feb 3;106(5):1518-23. Copyright 2009 National Academy of Sciences, U.S.A. J:144484
Associated
Alleles
Symbol Name
Il21rtm1Wjl interleukin 21 receptor; targeted mutation 1, Warren J Leonard
Yaa accelerated autoimmunity and lymphoproliferation transposition; accelerated autoimmunity and lymphoproliferation
Associated
Genotypes
Allelic Composition Genetic Background
Il21rtm1Wjl/Il21rtm1Wjl
X/Yaa 		BXSB.129(Cg)-Il21rtm1Wjl/Dcr
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory