Phenotype Image Detail

Image

Caption

Increased number of postsynaptic densities in mossy fiber-granule cell synapses in Kndc1^tm1Mnkm/Kndc1^tm1Mnkm cerebellum. (A) Representative electron microscopic images of cerebellar glomeruli in wild-type (WT) and Kndc1^tm1Mnkm/Kndc1^tm1Mnkm (KO) mice (8-week-old). Arrow heads indicate excitatory synapses between mossy fiber terminals (MFTs) and dendrites of cerebellar granule cells. High power views of each synaptic structure indicated by arrow heads are shown below. Scale bar, 1 um.

Copyright

This image is from Hayashi K, PLoS One 2017;12(3):e0173175, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:246827

Associated Alleles

Symbol	Name
Kndc1^tm1Mnkm	kinase non-catalytic C-lobe domain (KIND) containing 1; targeted mutation 1, Manabu Nakayama

Associated Genotypes

Allelic Composition	Genetic Background
Kndc1^tm1Mnkm/Kndc1^tm1Mnkm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J