Phenotype Image Detail

Image

Caption

Transmission electron microscopy of vestibular end organs in 4-month-old Tmprss3^m1Ingm/Tmprss3^m1Ingm mice. A and B, transverse section of crista. A, typical cytoarchitectural organization with both types of hair cells (black asterisks), type I and type II, lying on a layer of supporting cells (white asterisks). B, hair bundles (arrows) normally located at the top of hair cells above their cuticular plates. Type I hair cells (black asterisk) are recognizable by their typical afferent innervation, the calyx terminal (arrowheads) wrapping the basal part of the hair cell body. Nuclei of type II hair cells (upper right) are normally located higher in the epithelium. C and D, transverse section of utricule. C, organization of hair cells (black asterisks) and supporting cells (white asterisks) are also normally preserved in utricules. D, arrows point to hair bundles overhanging the two types of vestibular hair cells, type I (left black asterisk) and its typical calyx afferent (arrowheads) and type II (right black asterisk). E and F, transverse section of saccule. E, a few unidentified sensory cells (black asterisk) still lie on the layer of supporting cells (white asterisks) composing a thin epithelia penetrated by an undetermined type of afferents. Hair bundles are no longer observed in this section. F, at higher magnification, the sensory cell type (black asterisk) and the neighboring afferent terminal are still undetermined. Scale bars, 50 um (A), 10 um (C and E), and 1 um (B, D, and F).

Copyright

This image is from Fasquelle L, J Biol Chem 2011 May 13;286(19):17383-97 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:172676

Associated Alleles

Symbol	Name
Tmprss3^m1Ingm	transmembrane protease, serine 3; mutation 1, Ingenium Pharmaceuticals

Associated Genotypes

Allelic Composition	Genetic Background
Tmprss3^m1Ingm/Tmprss3^m1Ingm	C3HeB/FeJ-Tmprss3^m1Ingm