Phenotype Image Detail

Image

Caption

Central nervous system (CNS) vacuolization in Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} (aspa^lacZ/lacZ) mutants. Representative pictures of Nissl stained brain sections of wild-type (aspa^+/+) (A, C) and mutant (B, D) mice (4 months). Vacuoles are abundant in forebrain grey matter of cortex and thalamus while white matter of the corpus callosum is spared (B). In the hippocampus, the histopathology is exclusively seen in the pyramidal but not the dentate granule cell layer. Magnifications of thalamic areas show substantial spongy degeneration in the mutant (arrows in D) but not in the control (C). hc, hippocampus; cc, corpus callosum; ctx, cortex; dcl, granule cell layer; pcl, pyramidal cell layer; tha, thalamus. Bars: 400 um in A,B; 200 um in C,D.

Copyright

This image is from Mersmann N, PLoS One 2011;6(5):e20336, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172582

Associated Alleles

Symbol	Name
Aspa^tm1a(EUCOMM)Wtsi	aspartoacylase; targeted mutation 1a, Wellcome Trust Sanger Institute
Aspa^tm1a(EUCOMM)Wtsi	aspartoacylase; targeted mutation 1a, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Aspa^tm1a(EUCOMM)Wtsi/Aspa^tm1a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N