Phenotype Image Detail

Image

Caption

Myocardial ischemia/reperfusion injury (MIRI)-induced tissue loss following left anterior descending branch of the coronary artery (LAD) ligation and reperfusion in Masp2^tm1Wjsc/Masp2^tm1Wjsc mice and wild-type (WT) littermate controls. Hearts were subjected to 30 min of focal ischemia by occluding the LAD, followed by 120 min reperfusion. At the end of the experiments, the LAD was reoccluded and 5% Evans blue injected into the left ventricle (LV) to determine the risk zone (RZ). Hearts were excised, sectioned, and incubated at 37C for 30 min in 3% TTC solution, which is a metabolic stain. Nonperfused infarcted tissue remains colorless, nonperfused and noninfracted tissue (RZ) stains red, and normal perfused myocardium stains blue. Right panels are image-enhanced.

Copyright

This image is from Schwaeble WJ, Proc Natl Acad Sci U S A 2011 May 3;108(18):7523-8. Copyright 2011 National Academy of Sciences, U.S.A. J:172218

Associated Alleles

Symbol	Name
Masp2^tm1Wjsc	MBL associated serine protease 2; targeted mutation 1, Wilhelm J Schwaeble

Associated Genotypes

Allelic Composition	Genetic Background
Masp2^tm1Wjsc/Masp2^tm1Wjsc	B6.129P2-Masp2^tm1Wjsc