Phenotype Image Detail

Image

Caption

Increase of amyloid beta deposits and amyloid beta 40 in the hippocampus and cortex of Vps35^{Gt(RRK261)Byg}/Vps35⁺ Tg(APPSWE)2576Kha/0 mice. (A) Increase of amyloid beta deposits in 6-month or older Tg(APPSWE)2576Kha/0 Vps35^{Gt(RRK261)Byg}/Vps35⁺ (Tg2576+/-;Vps35+/m) brain as compared with that of Tg(APPSWE)2576Kha/0 (Tg2576+/-) brain by immunohistochemical staining analysis using anti-6E10 antibody.

Copyright

This image is from Wen L, J Cell Biol 2011 Nov 28;195(5):765-79, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:178937

Associated Alleles

Symbol	Name
Tg(APPSWE)2576Kha	transgene insertion 2576, Karen Hsiao Ashe
Vps35^Gt(RRK261)Byg	VPS35 retromer complex component; gene trap RRK261, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Vps35^Gt(RRK261)Byg/Vps35^+ Tg(APPSWE)2576Kha/0	involves: 129P2/OlaHsd * C57BL/6 * SJL