Phenotype Image Detail

Image

Caption

Representative M-mode echocardiographs from conscious control and Tg(tetO-Mir208a)#Dzw/0 Tg(Myh6-tTA)6Smbf/0 (miR-208a Tg) mice. IVSTD, interventricular septal thickness in diastole; IVSTS, interventricular septal thickness in systole; PWTD, posterior wall thickness in diastole; PWTS, posterior wall thickness in systole; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension. Analysis of cardiac function by echocardiography on 3-month-old animals revealed that hearts displayed thickening of the ventricular walls (anterior wall in diastole and systole, posterior wall in diastole), an increase in left ventricular diameter (left ventricular diameter in diastole and systole), and deterioration in cardiac function, as indicated by decreased fractional shortening.

Copyright

This image is from Callis TE, J Clin Invest 2009 Sep;119(9):2772-86 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152696

Associated Alleles

Symbol	Name
Tg(Myh6-tTA)6Smbf	transgene insertion 6, Section of Myocardial Biology - Fishman Lab
Tg(tetO-Mir208a)#Dzw	transgene insertion #, Da-Zhi Wnag

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Myh6-tTA)6Smbf/0 Tg(tetO-Mir208a)#Dzw/0	involves: C3H * C57BL/6 * CBA