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Phenotype Image Detail
Image
Caption Representative M-mode echocardiographs from conscious control and Tg(tetO-Mir208a)#Dzw/0 Tg(Myh6-tTA)6Smbf/0 (miR-208a Tg) mice. IVSTD, interventricular septal thickness in diastole; IVSTS, interventricular septal thickness in systole; PWTD, posterior wall thickness in diastole; PWTS, posterior wall thickness in systole; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension. Analysis of cardiac function by echocardiography on 3-month-old animals revealed that hearts displayed thickening of the ventricular walls (anterior wall in diastole and systole, posterior wall in diastole), an increase in left ventricular diameter (left ventricular diameter in diastole and systole), and deterioration in cardiac function, as indicated by decreased fractional shortening.
Copyright This image is from Callis TE, J Clin Invest 2009 Sep;119(9):2772-86 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152696
Associated
Alleles
Symbol Name
Tg(Myh6-tTA)6Smbf transgene insertion 6, Section of Myocardial Biology - Fishman Lab
Tg(tetO-Mir208a)#Dzw transgene insertion #, Da-Zhi Wnag
Associated
Genotypes
Allelic Composition Genetic Background
Tg(Myh6-tTA)6Smbf/0
Tg(tetO-Mir208a)#Dzw/0
involves: C3H * C57BL/6 * CBA

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory