Phenotype Image Detail

Image

Caption

Neuronal loss in the spiral and vestibular ganglia in Slitrk6^tm1.1Jaru/Slitrk6^tm1.1Jaru (-/-) mice. Number of neurons (A, D), volume (B, E), and incidence of cell death (C, F) in the spiral (A-C) and vestibular (D-F) ganglia. Both the number of neurons and volume of the spiral ganglion of the mutant mice were significantly lower than those of wild-type (WT) mice at E16.5, and they decreased to about a half of those of WT mice at P0 (A, B). Cell death in the spiral ganglion significantly increased in mutant mice at E16.5 and P0 (C). Both the number of neurons and the volume of the vestibular ganglion were significantly lower in the mutant than in the WT from E13.5, and both were about 75% of those of WT mice at E16.5 and P0 (D, E). Cell death in the vestibular ganglion was significantly increased in mutant mice at E13.5 and E16.5 (F). Measurements of mutant vestibular ganglia were made in inner ears without posterior crista innervation. n = 5 to 7 in the spiral ganglion and n = 3 to 5 in the vestibular ganglion. Mean + SD, * p<0.05, ** p<0.01, Student's t-test. H&E-stained spiral ganglia at E16.5 (G, K) and P0 (H, L) and vestibular ganglia at E13.5 (I, M) and P0 (J, N) of WT (G-J) and mutant mice (K-N). Pyknotic cells are frequently observed in the spiral ganglion of mutant mice at E16.5 (arrowheads in G, K). In the vestibular ganglion, the number of pyknotic cells is significantly increased at E13.5 in mutant mice (arrowheads in I, M). At P0, there are no apparent differences between WT and mutant mice in cell size and organization in either the spiral or vestibular ganglia (H, J, L, N). Scale bars: 50 um.

Copyright

This image is from Katayama K, PLoS One 2009;4(11):e7786, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155405

Associated Alleles

Symbol	Name
Slitrk6^tm1.1Jaru	SLIT and NTRK-like family, member 6; targeted mutation 1.1, Jun Aruga

Associated Genotypes

Allelic Composition	Genetic Background
Slitrk6^tm1.1Jaru/Slitrk6^tm1.1Jaru	B6.129P2-Slitrk6^tm1.1Jaru