Phenotype Image Detail

Image

Caption

Morphological changes in the prefrontal cortex of Hbegf^tm1Hhar/Hbegf^tm1Hhar Tg(Six3-cre)69Frty/0 (KO) mice. (a) Representative photomicrographs showing morphology of pyramidal neuronsin cortical layer III of the prefrontal cortex from control (left) and mutant (right) mice. Scale bar = 20 um. (b) Representative photomicrographs of apicaldendritic segments from control (left) and mutant (right) mice. Scale bar = 8 um. (c) High-magnification images of apical dendritic segments from adult control (left) and mutant (right) mice. In pyramidal neurons, spine density is reduced, although dendritic length is normal. Scale bar = 2 um.

Copyright

This image is from Oyagi A, PLoS One 2009;4(10):e7461, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:154094

Associated Alleles

Symbol	Name
Hbegf^tm1Hhar	heparin-binding EGF-like growth factor; targeted mutation 1, Hideaki Hara
Tg(Six3-cre)69Frty	transgene insertion 69, Yasuhide Furuta

Associated Genotypes

Allelic Composition	Genetic Background
Hbegf^tm1Hhar/Hbegf^tm1Hhar Tg(Six3-cre)69Frty/0	involves: C57BL/6 * CBA * DBA/2