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Phenotype Image Detail
Image
Caption BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2tm1Dlo/Bcl2tm1Dlo mice. (A) Kidney histology illustrates the dramatic polycystic disease in Bcl2tm1Dlo/Bcl2tm1Dlo (Bcl-2-/-Bim+/+) mice and its prevention by deletion of a single Bcl2l11 (Bim) allele or subtle mutations in Bcl2l11.(BimP/P = Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui; BimB/B = Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui; BimB/N = Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui; BimN/N = Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui). (B) Spleens of mice show that BH3 replacements in Bcl2l11 significantly restore the structure and size of the spleen in Bcl2-deficient animals. Bars, 1 mm.
Copyright This image is from Merino D, J Cell Biol 2009 Aug 10;186(3):355-62, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:153846
Associated
Alleles
Symbol Name
Bcl2l11tm1.1Boui BCL2 like 11; targeted mutation 1.1, Philippe Bouillet
Bcl2l11tm2.1Boui BCL2 like 11; targeted mutation 2.1, Philippe Bouillet
Bcl2l11tm3.1Boui BCL2 like 11; targeted mutation 3.1, Philippe Bouillet
Bcl2tm1Dlo B cell leukemia/lymphoma 2; targeted mutation 1, Dennis Y Loh
Associated
Genotypes
Allelic Composition Genetic Background
Bcl2tm1Dlo/Bcl2tm1Dlo B6.129P2-Bcl2tm1Dlo
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
B6.Cg-Bcl2tm1Dlo Bcl2l11tm2.1Boui
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory