Phenotype Image Detail

Image

Caption

G, H, Immunohistochemical staining with an antiacetylated alpha-tubulin showed densely clustered cilia in the wild-type (Ulk4+/+) (G, white arrowhead), but fewer and disorganized cilia (H, white arrowhead) and absence of cilia (H, white arrow) in Ulk4^{tm1a(KOMP)Wtsi}/Ulk4^{tm1a(KOMP)Wtsi} (Ulk4-/-) mice. I, J, Scanning electron microscopy confirmed highly organized cilia in heterozygous (I) mice, but disorganized/dysfunctional cilia, with the absence of cilia in large areas of mutant (J) mice. Scale bars: A-J, 100 um.

Copyright

This image is from Liu M, J Neurosci 2016 Jul 20;36(29):7589-600, an open-access article distributed under the terms of the Creative Commons Attribution-Noncommerical-NoDerivatives 4.0 International License. J:234631

Associated Alleles

Symbol	Name
Ulk4^tm1a(KOMP)Wtsi	unc-51-like kinase 4; targeted mutation 1a, Wellcome Trust Sanger Institute
Ulk4^tm1a(KOMP)Wtsi	unc-51-like kinase 4; targeted mutation 1a, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Ulk4^tm1a(KOMP)Wtsi/Ulk4^tm1a(KOMP)Wtsi	involves: C57BL/6N