Phenotype Image Detail

Image

Caption

Ulk4^{tm1a(KOMP)Wtsi}/Ulk4^{tm1a(KOMP)Wtsi} mice display hydrocephalus phenotype at P12. A-L, H&E-stained brain sections of wild-type (WT) littermate mice (A-C, G, I, K ) and P12 mutant brain sections (D-F, H, J, L). M, N, Scanning electron microscopy images of WT (M) and mutant (N) aqueduct, showing aqueductal blockage in the mutant (N). O, P, Images of brain slice at the 4V (arrow) from WT (O) and mutant (P) mice. Q-U, Statistical quantifications show significantly enlarged LV (R), 3V (S), and SCO ventricles (U). Scale bars: A-F, 1 mm; G-J, 50 um; K, L, 100 um; M, N, insets, 500 um; M-P, 200 um. *p <0.05; **p <0.01. Aq, Aqueduct; LV, lateral ventricle; pc, posterior commissure; RF, Reissner's fiber; SCO, subcommissural organ.

Copyright

This image is from Liu M, J Neurosci 2016 Jul 20;36(29):7589-600, an open-access article distributed under the terms of the Creative Commons Attribution-Noncommerical-NoDerivatives 4.0 International License. J:234631

Associated Alleles

Symbol	Name
Ulk4^tm1a(KOMP)Wtsi	unc-51-like kinase 4; targeted mutation 1a, Wellcome Trust Sanger Institute
Ulk4^tm1a(KOMP)Wtsi	unc-51-like kinase 4; targeted mutation 1a, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Ulk4^tm1a(KOMP)Wtsi/Ulk4^tm1a(KOMP)Wtsi	involves: C57BL/6N