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Phenotype Image Detail
Image
Caption Sections of the pulmonic valve and low-magnification images of the growth plates of the femur and tibia of newborn wild-type (WT), Rhbdf1tm1b(EUCOMM)Wtsi/Rhbdf1tm1b(EUCOMM)Wtsi Rhbdf2tm1Mak/Rhbdf2tm1Mak (iR1/2-/-), Adam17tm1.1Bbl/Adam17tm1.1Bbl (Adam17-/-), Rhbdf1tm1b(EUCOMM)Wtsi/Rhbdf1tm1b(EUCOMM)Wtsi (iR1-/-), and Rhbdf2tm1Mak/Rhbdf2tm1Mak (iR2-/-) mice. Arrows point to the pulmonic valve leaflets, which are thickened in relationship to their length in newborn Rhbdf1tm1b(EUCOMM)Wtsi/Rhbdf1tm1b(EUCOMM)Wtsi Rhbdf2tm1Mak/Rhbdf2tm1Mak and Adam17tm1.1Bbl/Adam17tm1.1Bbl mice when compared with WT controls, whereas the pulmonic valve leaflets in Rhbdf1tm1b(EUCOMM)Wtsi/Rhbdf1tm1b(EUCOMM)Wtsi and Rhbdf2tm1Mak/Rhbdf2tm1Mak mice resemble WT controls. [Scale bars, 100 um (B, Top) and 500 um (B, Bottom).]
Copyright This image is from Li X, Proc Natl Acad Sci U S A 2015 May 12;112(19):6080-5. Copyright 2015 National Academy of Sciences, U.S.A. J:221411
Associated
Alleles
Symbol Name
Adam17tm1.1Bbl a disintegrin and metallopeptidase domain 17; targeted mutation 1.1, Carl P Blobel
Rhbdf1tm1b(EUCOMM)Wtsi rhomboid 5 homolog 1; targeted mutation 1b, Wellcome Trust Sanger Institute
Rhbdf2tm1Mak rhomboid 5 homolog 2; targeted mutation 1, Tak Mak
Associated
Genotypes
Allelic Composition Genetic Background
Rhbdf1tm1b(EUCOMM)Wtsi/Rhbdf1tm1b(EUCOMM)Wtsi
Rhbdf2tm1Mak/Rhbdf2tm1Mak
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * FVB/N
Adam17tm1.1Bbl/Adam17tm1.1Bbl involves: 129P2/OlaHsd * C57BL/6 * FVB/N

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory