Phenotype Image Detail

Image

Caption

Sections of the pulmonic valve and low-magnification images of the growth plates of the femur and tibia of newborn wild-type (WT), Rhbdf1^{tm1b(EUCOMM)Wtsi}/Rhbdf1^{tm1b(EUCOMM)Wtsi} Rhbdf2^tm1Mak/Rhbdf2^tm1Mak (iR1/2-/-), Adam17^tm1.1Bbl/Adam17^tm1.1Bbl (Adam17-/-), Rhbdf1^{tm1b(EUCOMM)Wtsi}/Rhbdf1^{tm1b(EUCOMM)Wtsi} (iR1-/-), and Rhbdf2^tm1Mak/Rhbdf2^tm1Mak (iR2-/-) mice. Arrows point to the pulmonic valve leaflets, which are thickened in relationship to their length in newborn Rhbdf1^{tm1b(EUCOMM)Wtsi}/Rhbdf1^{tm1b(EUCOMM)Wtsi} Rhbdf2^tm1Mak/Rhbdf2^tm1Mak and Adam17^tm1.1Bbl/Adam17^tm1.1Bbl mice when compared with WT controls, whereas the pulmonic valve leaflets in Rhbdf1^{tm1b(EUCOMM)Wtsi}/Rhbdf1^{tm1b(EUCOMM)Wtsi} and Rhbdf2^tm1Mak/Rhbdf2^tm1Mak mice resemble WT controls. [Scale bars, 100 um (B, Top) and 500 um (B, Bottom).]

Copyright

This image is from Li X, Proc Natl Acad Sci U S A 2015 May 12;112(19):6080-5. Copyright 2015 National Academy of Sciences, U.S.A. J:221411

Associated Alleles

Symbol	Name
Adam17^tm1.1Bbl	a disintegrin and metallopeptidase domain 17; targeted mutation 1.1, Carl P Blobel
Rhbdf1^tm1b(EUCOMM)Wtsi	rhomboid 5 homolog 1; targeted mutation 1b, Wellcome Trust Sanger Institute
Rhbdf2^tm1Mak	rhomboid 5 homolog 2; targeted mutation 1, Tak Mak

Associated Genotypes

Allelic Composition	Genetic Background
Rhbdf1^tm1b(EUCOMM)Wtsi/Rhbdf1^tm1b(EUCOMM)Wtsi Rhbdf2^tm1Mak/Rhbdf2^tm1Mak	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * FVB/N
Adam17^tm1.1Bbl/Adam17^tm1.1Bbl	involves: 129P2/OlaHsd * C57BL/6 * FVB/N