Phenotype Image Detail

Image

Caption

Bright and fluorescent images of Neurofilament of beta-tubulin innunostained E9.5-10.5 (a) wild-type and (b) arco/arco (arco piccolo) embryos. Arrowheads and arrows highlight agenesis or hypoplasia of neuronal differentiation in the midbrain and cranial ganglia. Mutant embryos exhibit only a rudimentary neuronal differentiation within the cranial ganglia and a complete lack of neuronal differentiation within the midbrain (arrowheads). The ganglia appear reduced and axonal branching of the trigeminal and facial ganglia is lacking. The glossopharyngeal ganglion is abnormally fused with the vagal and nerves from this combined ganglion projects ectopically towards the facial ganglion (arrows). Abbreviations: pl, plexus; f, facioacoustic/vestibule cochlear; g, glossopharyngeal; tg, trigeminal; v. vagal.

Copyright

This image is from Sandell LL, Genesis 2011 Apr;49(4):342-59, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:171522

Associated Alleles

Symbol	Name
arco	arco piccolo

Associated Genotypes

Allelic Composition	Genetic Background
arco/arco	involves: 129S1/Sv * C57BL/6 * FVB/NJ