Phenotype Image Detail

Image

Caption

Hydrocephalus and disrupted laminar organization of Bicd2^tm1.1Hgrd/Bicd2^tm1.1Hgrd cortex. Macroscopic images (A-C) and coronal thionin-stained section of P10 nervous system showing enormous expansion of caudal lateral ventricles (LV, arrow in C) and thinning of the cortex (arrows in A B) in Bicd2^tm1.1Hgrd/Bicd2^tm1.1Hgrd brain. Also note disorganized pyramidal layer in the hippocampus (arrow in D) and smaller cerebellum (green contour). (E) Coronal sections at the level of the mesencephalon showing the aqueduct. Sections are processed for neurofilament-M immunohistochemistry and counterstained with thionin. Note the absence of a clear lumen in the mutant aqueduct indicative of aqueductal stenosis.

Copyright

This image is from Jaarsma D, Nat Commun 2014;5():3411, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:210236

Associated Alleles

Symbol	Name
Bicd2^tm1.1Hgrd	BICD cargo adaptor 2; targeted mutation 1.1, Casper Hoogenraad

Associated Genotypes

Allelic Composition	Genetic Background
Bicd2^tm1.1Hgrd/Bicd2^tm1.1Hgrd	involves: C57BL/6